April 27, 2026Journal of the American College of Cardiology
Impact of Low Flow on the Outcome of High-Risk Patients Undergoing Transcatheter Aortic Valve Replacement
Why the study?
Low flow is associated with worse outcomes following surgical aortic valve replacement, but there are few data regarding its impact on outcomes following TAVR.
Does baseline low flow predict increased mortality in high-risk patients with severe aortic stenosis undergoing TAVR?
Population
639 patients undergoing TAVR for symptomatic severe AS in 2 Canadian centers
Comparison
Low flow (SVi <35 ml/m2) vs normal flow
Design
Retrospective analysis of prospectively collected data
Follow-up
2 years
Authors
Discussion
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Member takes
Overview
Low flow merits heightened vigilance in TAVR risk stratification; leaves open whether targeted flow optimization improves outcomes.**[[1]](https://pubmed.ncbi.nlm.nih.
Structured PICO
Does baseline low flow predict increased mortality in high-risk patients with severe aortic stenosis undergoing TAVR?
P
Population
639 high-risk patients with symptomatic severe aortic stenosis undergoing transcatheter aortic valve replacement (TAVR) in 2 Canadian centers.
I
Intervention
Baseline low flow (stroke volume index <35 ml/m2)
C
Comparator
Baseline normal flow (stroke volume index ≥35 ml/m2)
O
Outcome
30-day mortality, cumulative all-cause mortality, and cumulative cardiovascular mortalityhard clinical
Baseline low flow (SVi <35 ml/m2), but not low LVEF or low gradient, is an independent predictor of early and late mortality following TAVR in high-risk patients with severe aortic stenosis.
Cite This Study
Ven et al. (2013) studied this question.