November 8, 2005Circulation266 citations
View Full PaperMineralocorticoid Receptor Antagonism Ameliorates Left Ventricular Diastolic Dysfunction and Myocardial Fibrosis in Mildly Symptomatic Patients With Idiopathic Dilated Cardiomyopathy
Structured PICO
Does spironolactone improve LV diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy?
P
Population
Mildly symptomatic patients with idiopathic dilated cardiomyopathy (DCM)
I
Intervention
Spironolactone
O
Outcome
Left ventricular diastolic dysfunction and myocardial fibrosissurrogate
Spironolactone improves diastolic function and reduces myocardial fibrosis in mildly symptomatic DCM patients, specifically those with baseline collagen accumulation.
Abstract
Spironolactone ameliorated LV diastolic dysfunction and reduced chamber stiffness in association with regression of myocardial fibrosis in mildly symptomatic patients with DCM. These effects appeared limited, however, to patients with increased myocardial collagen accumulation.