June 27, 2012Hypertension
Renal Hemodynamics and Renal Function After Catheter-Based Renal Sympathetic Denervation in Patients With Resistant Hypertension
Why the study?
Does catheter-based sympathetic renal denervation improve blood pressure, renal hemodynamics, and renal function in patients with resistant hypertension?
Population
100 consecutive patients with resistant hypertension
Comparison
Catheter-based sympathetic renal denervation (RD) vs Control group (no renal denervation)
Design
Cohort
Follow-up
6 months
Authors
Discussion
Loading...
Member takes
Implication
Renal denervation may be considered in resistant hypertension; leaves open need for randomized confirmation of durability and outcomes.
Key Points
- This study investigates the impact of catheter-based renal sympathetic denervation on renal hemodynamics and function in patients with resistant hypertension.
- One hundred patients with resistant hypertension participated; 88 received renal sympathetic denervation and 12 served as controls.
- Blood pressure, renal resistive index, and urinary albumin levels were measured before treatment and at 3 and 6 months post-procedure.
- Follow-up assessed for adverse effects such as renal artery stenoses or dissections.
- Systolic blood pressure decreased by 22.7 mm Hg at 3 months and by 26.6 mm Hg at 6 months (P<0.001).
- Renal resistive index decreased from 0.691 at baseline to 0.670 by 6 months (P=0.017).
- The occurrence of microalbuminuria and macroalbuminuria decreased following renal sympathetic denervation.
Structured PICO
Does catheter-based sympathetic renal denervation improve blood pressure, renal hemodynamics, and renal function in patients with resistant hypertension?
P
Population
100 consecutive patients with resistant hypertension
I
Intervention
Catheter-based sympathetic renal denervation (RD)
C
Comparator
Control group (no renal denervation)
O
Outcome
Systolic, diastolic, and pulse pressure, renal resistive index in interlobar arteries, renal function, and urinary albumin excretion at 3 and 6 months of follow-upsurrogate
Catheter-based renal denervation safely reduces blood pressure and improves renal hemodynamics without adversely affecting renal function in patients with resistant hypertension.
Cite This Study
Mahfoud et al. (2012) studied this question.