What question did this study set out to answer?

To evaluate the long-term efficacy, durability, and safety of catheter-based renal sympathetic denervation over two years in patients with resistant hypertension.

March 15, 2011HypertensionOpen Access

Catheter-Based Renal Sympathetic Denervation for Resistant Hypertension

View Full Paper

Ask AI

Bookmark

Why the study?

Does catheter-based renal sympathetic denervation reduce blood pressure in patients with resistant hypertension?

Population

153 patients with resistant hypertension, mean age 57±11 years, 39% women, multinational.

Design

Cohort

Follow-up

24 months

Discussion

Member takes

Implication

May support renal denervation in resistant hypertension; leaves open randomized confirmation of benefit.

Key Points

To evaluate the long-term efficacy, durability, and safety of catheter-based renal sympathetic denervation over two years in patients with resistant hypertension.
Treated 153 patients with resistant hypertension (systolic BP ≥160 mm Hg despite taking ≥3 antihypertensive medications including a diuretic) across 19 centers in Australia, Europe, and the United States in a nonrandomized manner.
Performed catheter-based renal sympathetic denervation utilizing radiofrequency energy ablation, with a median ablation duration of 38 minutes.
The intervention was completed without complication in 97% of patients (149 of 153); four procedural complications occurred (three groin pseudoaneurysms and one renal artery dissection) and were managed without subsequent sequelae.
Postprocedure office blood pressure dropped substantially from a baseline mean of 176/98 mm Hg, achieving sustained reductions of 20/10, 24/11, 25/11, 23/11, 26/14, and 32/14 mm Hg at 1, 3, 6, 12, 18, and 24 months, respectively.

Structured PICO

Does catheter-based renal sympathetic denervation reduce blood pressure in patients with resistant hypertension?

Population

153 patients with resistant hypertension (systolic BP ≥160 mm Hg on ≥3 antihypertension drugs, including a diuretic), mean age 57±11 years, 39% women, multinational (Australia, Europe, and the United States).

Intervention

Catheter-based renal sympathetic denervation using radiofrequency energy ablation

Outcome

Reduction in office blood pressure at up to 24 monthssurrogate

Catheter-based renal sympathetic denervation provides substantial and sustained blood pressure reduction up to 24 months in patients with resistant hypertension.

Cite This Study

A 2011 study studied this question.

synapsesocial.com/papers/6a7ca5a650d6249878ba486b https://doi.org/10.1161/hypertensionaha.110.163014

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Catheter-Based Renal Sympathetic Denervation for Resistant Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Catheter-Based Renal Sympathetic Denervation for Resistant Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider