Noninvasive determination of left ventricular end-systolic stress: validation of the method and initial application.

12 subjects (4 with atypical chest pain, 6 with severe aortic regurgitation, 2 with congestive cardiomyopathy) for validation; and additional cohorts for clinical application including 22 normal subjects, 14 treated hypertensives, 15 patients with symptomatic aortic regurgitation, and 4 patients with congestive cardiomyopathy.

Noninvasive estimation of end-systolic left ventricular (LV) meridional wall stress based on M-mode LV echographic end-systolic diameter, posterior wall thickness, and cuff systolic arterial pressure.

Simultaneous invasive LV wall stress derived from micromanometer LV pressure recordings and continuously digitized echograms.

Correlation between noninvasive and invasive end-systolic LV meridional wall stress.surrogate