Key result
DES linked to ~94% higher neoatherosclerosis incidence versus BMS, occurring at shorter implant durations.
Population
299 autopsy cases with 406 stented coronary lesions implanted for >30 days
Comparison
BMS vs DES (SES and PES)
Design
Registry-based autopsy study
Authors
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Warrants vigilance for very late DES failure; leaves open significance of neoatherosclerosis in modern stent generations.
Observational (n=299)
Absolute Event Rate: 31% vs 16%
p-value: p=<0.001
Nakazawa et al. (2011) conducted an observational in Coronary artery disease with stent implantation (n=299). Drug-eluting stents (DES) vs. Bare-metal stents (BMS) was evaluated on Incidence of neoatherosclerosis (p=<0.001). Drug-eluting stents had a significantly higher incidence of neoatherosclerosis compared to bare-metal stents (31% vs 16%; p<0.001), occurring at a shorter median implant duration.
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