Neuroendocrine prediction of left ventricular function and heart failure after acute myocardial infarction
Why the study?
Does early measurement of plasma BNP predict left ventricular function, heart failure, and death in patients with acute myocardial infarction?
Structured PICO
Does early measurement of plasma BNP predict left ventricular function, heart failure, and death in patients with acute myocardial infarction?
P
Population
220 patients admitted with acute myocardial infarction to a single coronary care unit.
I
Intervention
Measurement of plasma levels of brain natriuretic peptide (BNP), atrial natriuretic factor (ANF), N-terminal ANF (N-ANF), cyclic guanosine monophosphate (cGMP), and plasma catecholamines 1-4 days after myocardial infarction.
O
Outcome
Left ventricular ejection fraction (LVEF) at 3-5 months, death, and onset of left ventricular failure over a mean period of 14 months.hard clinical
Plasma BNP measured early after acute myocardial infarction is a powerful independent predictor of subsequent left ventricular dysfunction, heart failure, and death.
Authors
Discussion
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Implication
May support post-MI risk stratification; leaves open whether measurement alters outcomes in prospective trials.
Cite This Study
Richards et al. (1999) studied this question.