November 1, 1969Journal of Clinical InvestigationOpen Access

Autonomic blockade by propranolol and atropine to study intrinsic myocardial function in man

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Why the study?

Does autonomic blockade with propranolol and atropine reveal intrinsic myocardial function abnormalities in patients with myocardial disease?

Population

47 patients with normal hearts and known graded myocardial disease undergoing cardiac catheterization

Comparison

Intravenous injection of 0.2 mg/kg propranolol… vs Pre-blockade baseline and comparison between…

Design

Other

Authors

AJAnthony D. JoseJawaharlal Institute of Post Graduate Medical Education and Research RTRoger R. TaylorBoston University

Discussion

Member takes

Implication

May support intrinsic HR post-blockade as myocardial severity index; hypothesis-generating, should not yet change practice.

Structured PICO

Does autonomic blockade with propranolol and atropine reveal intrinsic myocardial function abnormalities in patients with myocardial disease?

Population

47 patients with normal hearts and known graded myocardial disease undergoing cardiac catheterization

Intervention

Intravenous injection of 0.2 mg/kg propranolol and 0.04 mg/kg atropine

Comparator

Pre-blockade baseline and comparison between normal and diseased hearts

Outcome

Intrinsic cardiac function (hemodynamic parameters including intrinsic heart rate, stroke volume, and left ventricular filling pressure)surrogate

Autonomic blockade with propranolol and atropine reveals that intrinsic heart rate is quantitatively related to the severity of myocardial disease, suggesting its potential as a simple index of myocardial function.

Cite This Study

Jose et al. (1969) studied this question.

synapsesocial.com/papers/69f14b962811130d0cde2231 https://doi.org/10.1172/jci106167

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