July 15, 1997Circulation
Cardiac Atrophy After Bed-Rest Deconditioning
Why the study?
Does 2 weeks of bed rest with -6 degrees head-down tilt alter cardiac mechanics and orthostatic tolerance in young subjects?
Population
12 subjects, aged 24+/-5 years
Comparison
2 weeks of bed rest with -6 degrees head-down tilt vs Baseline measurements before bed rest
Design
Cohort
Follow-up
2 weeks
Authors
Discussion
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Member takes
Implication
Bed rest-associated cardiac changes may heighten orthostatic intolerance risk; hypothesis-generating for deconditioning mechanisms in clinical populations.
Structured PICO
Does 2 weeks of bed rest with -6 degrees head-down tilt alter cardiac mechanics and orthostatic tolerance in young subjects?
P
Population
12 subjects, aged 24+/-5 years
I
Intervention
2 weeks of bed rest with -6 degrees head-down tilt
C
Comparator
Baseline measurements before bed rest
O
Outcome
Changes in cardiac mechanics including pulmonary capillary wedge pressure (PCWP), stroke volume (SV), left ventricular end-diastolic volume (LVEDV), left ventricular mass, pressure-volume curves, and orthostatic tolerancesurrogate
Two weeks of bed rest leads to a smaller, less distensible left ventricle and a steeper Starling relationship, contributing to orthostatic intolerance.
Cite This Study
Levine et al. (1997) studied this question.