Pericardial Fat, Intrathoracic Fat, and Measures of Left Ventricular Structure and Function
Why the study?
Are pericardial fat and intrathoracic fat independently associated with measures of left ventricular structure and function?
Population
997 participants from the Framingham Heart Study, 54.4% women
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Systemic obesity effects outweigh local pericardial fat on cardiac structure; hypothesis-generating and should not yet change practice.
Structured PICO
Are pericardial fat and intrathoracic fat independently associated with measures of left ventricular structure and function?
P
Population
997 participants from the Framingham Heart Study, 54.4% women
I
Intervention
Pericardial fat, intrathoracic fat, and visceral adipose tissue quantified from multidetector computed tomography, along with body mass index and waist circumference
O
Outcome
Cardiovascular magnetic resonance measures of left ventricular (LV) mass, LV end-diastolic volume, and left atrial dimensionsurrogate
The systemic effects of obesity on cardiac structure and function appear to outweigh the local pathogenic effects of pericardial fat, as associations between pericardial fat and cardiac measures are largely not independent of visceral adiposity.
Cite This Study
Fox et al. (2009) studied this question.