Key result
Hypertension was associated with greater aortic plaque burden (P<0.02), and among nonhypertensive subjects, women had a greater prevalence of aortic plaque than men (P<0.006).
Why the study?
Do age, sex, and hypertension impact aortic atherosclerotic burden in a free-living cohort?
Cohort (n=1,763)
Do age, sex, and hypertension impact aortic atherosclerotic burden in a free-living cohort?
Subclinical aortic atherosclerosis is prevalent and increases with age and hypertension, with a notably higher burden in non-hypertensive women compared to men.
Answers are grounded in this paper and cite their sources.
May support targeted aortic imaging in hypertensives and nonhypertensive women; leaves open causal roles and screening thresholds.
Objective— The purpose of this study was to investigate the impact of age, sex, and hypertension (HTN) on aortic atherosclerotic burden using cardiovascular MRI (CMR) in a free-living longitudinally followed cohort. Methods and Results— 1763 participants (829 M and 934 F; 38 to 88 years of age) of the Framingham Heart Study Offspring cohort underwent CMR of the thoracoabdominal aorta using an ECG-gated 2D T2-weighted black-blood sequence. Of these, 1726 subjects (96%) with interpretable CMR were characterized by sex, age-quartile, and presence or absence of HTN and clinical cardiovascular disease (CVD). Aortic plaque prevalence and volume increased with increasing age in both sexes. For the nonhypertensive (no-HTN) group, plaque was identified in 702 (46%) with greater prevalence in women than in men ( P <0.006). HTN was associated with greater aortic plaque burden ( P <0.02). The 200 subjects with clinical CVD had greater plaque burden than subjects without CVD ( P <0.0001). Conclusions— In this free-living longitudinally followed cohort, subclinical aortic atherosclerosis was seen in nearly half of subjects and increased with advancing age. HTN was associated with increased aortic plaque burden. Among no-HTN subjects, women had greater plaque burden than men. These data suggest that subclinical atherosclerosis is more common in no-HTN women and emphasize the importance of focusing on preventive measures in both sexes.
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Oyama et al. (2007) conducted a cohort in Aortic atherosclerosis (n=1,763). Hypertension, age, and sex vs. No hypertension, younger age, and male sex was evaluated on Aortic plaque prevalence and volume (p=<0.02). Hypertension was associated with greater aortic plaque burden (P<0.02), and among nonhypertensive subjects, women had a greater prevalence of aortic plaque than men (P<0.006).
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