Why the study?
Despite the frequency of mitral annulus calcification and its association with cardiovascular disease, arrhythmias, and mortality, its clinical relevance is grossly underappreciated.
Mitral annulus calcification is a clinically relevant entity associated with adverse cardiovascular outcomes and has important implications for transcatheter mitral valve replacement.
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MAC signals elevated cardiovascular risk but should not yet change practice; leaves open questions of causality and therapeutic targeting.
Abramowitz et al. (2015) studied this question.
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