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November 29, 2025SHILAP Revista de lepidopterologíaOpen Access

Compared to individuals in the lowest Gensini tertile (T1), those in the highest tertile (T3) exhibited a significant increase in 30-day all-cause mortality (HR 2.376, 95% CI: 1.004–5.623; P for trend = 0.039).

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Why the study?

Few studies have validated the association between Gensini scores and mortality among patients with acute coronary syndrome.

Does a higher Gensini score predict increased 30-day all-cause mortality in patients with acute coronary syndrome?

Population

2,742 ACS patients undergoing hospitalization and coronary angiography from 2 centers in China

Comparison

CAD severity categorized into Gensini score tertiles: T1 (< 42) vs T2 (42 ≤ score < 76) vs T3 (score ≥ 76)

Design

Two-center observational study

Follow-up

30 days

Authors

YZYi ZhangRLRong LuoXSXiaochen Sun

Discussion

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Member takes

Overview

May aid early ACS mortality stratification; hypothesis-generating and should not yet change practice.

Structured PICO

Does a higher Gensini score predict increased 30-day all-cause mortality in patients with acute coronary syndrome?

P
Population
2,742 Chinese patients diagnosed with acute coronary syndrome (ACS) who underwent hospitalization and coronary angiography between August 2014 and November 2019 from 2 centers in China.
I
Intervention
Higher Gensini score (tertile 3: score ≥ 76, or tertile 2: 42 ≤ score < 76) assessing severity of coronary artery disease.
C
Comparator
Lower Gensini score (tertile 1: score < 42).
O
Outcome
30-day all-cause mortality.hard clinical

Higher Gensini scores are positively associated with 30-day all-cause mortality in patients with acute coronary syndrome, highlighting its utility as a simple tool for early risk stratification.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/69f41d4ef3e494ed2b7d046dhttps://doi.org/10.1186/s12872-025-05303-5
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