Why the study?
Do coronary scores (Gensini, Leaman, ACC/AHA) predict major adverse cardiovascular events in patients with acute coronary syndrome?
Do coronary scores (Gensini, Leaman, ACC/AHA) predict major adverse cardiovascular events in patients with acute coronary syndrome?
The Gensini score provides valuable prognostic information for predicting MACE and cardiogenic death in patients with acute coronary syndrome.
Answers are grounded in this paper and cite their sources.
Gensini score may refine prognostication in ACS; extends observational data on angiographic scores but should not yet change practice.
BACKGROUND: The aim of the present study was to explore the association of 3 coronary scores with major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS). METHODS AND RESULTS: The 958 consecutive patients with ACS were followed up until either MACE or 31(st) December 2008 occurred; 257 patients reached clinical endpoints. Cox regression analysis demonstrated that the Gensini score was associated with 90-day MACE (relative risk (RR) 1.021, P=0.004), 6-month MACE (RR 1.021, P<0.001), 1-year MACE (RR 1.017, P=0.002), and MACE during follow-up (RR 1.010, P=0.040). Leaman score was associated with 90-day MACE (RR 1.094, P=0.014), 6-month MACE (RR 1.098, P=0.002), and 1-year MACE (RR 1.074, P=0.009). The logistic regression analysis demonstrated that the Gensini score (odds ratio (OR) 1.037, P=0.001), Leaman score (OR 1.165, P=0.007) and American College of Cardiology/American Heart Association (ACC/AHA) score (OR 1.235, P=0.025) were all associated with cardiogenic death. CONCLUSIONS: The Gensini score provides more valuable prognostic information on cardiovascular risk than either the Leaman or ACC/AHA score in patients with ACS.
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Huang et al. (2010) studied this question.
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