Tricuspid transcatheter edge-to-edge repair acutely reduced right ventricular preload and increased forward stroke volume, reflecting substantial RV unloading (P=0.03).
Observational (n=9)
Does tricuspid transcatheter edge-to-edge repair acutely improve right ventricular hemodynamics in patients with severe tricuspid regurgitation?
Tricuspid transcatheter edge-to-edge repair acutely improves right ventricular hemodynamics by reducing preload and increasing forward stroke volume without altering contractility.
p-value: p==0.03
BACKGROUND: Tricuspid transcatheter edge-to-edge repair is an established therapy for high-grade tricuspid regurgitation, but its acute impact on right ventricular (RV) mechanics remains incompletely understood. The aim of the study was to quantify the acute hemodynamic effects of tricuspid transcatheter edge-to-edge repair on RV function using invasive pressure-volume analysis. METHODS: Nine patients with severe tricuspid regurgitation (grades III-IV) underwent simultaneous invasive and echocardiographic assessment of RV function. A 7-electrode conductance catheter positioned in the RV continuously recorded pressure-volume signals, calibrated against 3-dimensional echocardiographic RV volumes. Steady-state RV pressure-volume loops and RV echocardiography were obtained before and after the procedure. RESULTS: =0.03), reflecting substantial RV unloading. CONCLUSIONS: Successful tricuspid transcatheter edge-to-edge repair is accompanied by economization of myocardial work through redirection of blood flow into the pulmonary circulation. Forward stroke volume increased while contractility and stroke work remained unchanged. Preload was significantly reduced, indicating an improved preload reserve.
Reil et al. (Wed,) conducted a observational in Severe tricuspid regurgitation (grades III-IV) (n=9). Tricuspid transcatheter edge-to-edge repair vs. Baseline (before procedure) was evaluated on Acute hemodynamic effects on right ventricular function (p==0.03). Tricuspid transcatheter edge-to-edge repair acutely reduced right ventricular preload and increased forward stroke volume, reflecting substantial RV unloading (P=0.03).