Does tricuspid TEER alter biventricular cardiac mechanics in patients with severe tricuspid regurgitation?
Tricuspid TEER provides immediate favorable hemodynamic effects by unloading the right ventricle, enhancing its contractility, and increasing left ventricular preload.
BACKGROUND: Transcatheter edge-to-edge repair (TEER) is an established therapy for severe tricuspid regurgitation (TR). Invasive pressure-volume (PV) analysis is the gold standard for characterizing ventricular function and ventricular-vascular interactions. The effects of tricuspid TEER on biventricular PV relationships are unknown. OBJECTIVES: ) ratio; and 3) metabolic demand, represented by PV area (PVA). METHODS: We used a conductance catheter to determine RV and LV PV relationships before and after tricuspid TEER. Pre- and postprocedural changes in cardiac mechanics were compared using the paired-samples t-test or Wilcoxon signed rank test. RESULTS: , PVA, and stroke work-to-PVA remained unchanged. CONCLUSIONS: TR reduction with tricuspid TEER generated immediate RV volume unloading, increased RV afterload, and enhanced RV contractility, maintaining forward stroke volume and increasing LV preload.
Mondellini et al. (2026) studied this question.
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