Antecedent hypertension and heart failure after myocardial infarction
Why the study?
No previous report had documented serial postinfarction neurohumoral status, serial left ventricular imaging, and clinical outcomes over prolonged follow-up in patients with and without antecedent hypertension.
Does antecedent hypertension increase the risk of heart failure, adverse ventricular remodeling, and mortality in patients after myocardial infarction?
Population
1,093 consecutive patients with acute MI
Comparison
Hypertensive vs normotensive patients
Design
Cohort study
Follow-up
Mean two years
Authors
Discussion
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Member takes
Implication
** Prompts closer HF surveillance after MI in those with antecedent hypertension; leaves open whether targeted anti-remodeling therapies improve outcomes.[[1]](https://www.jacc.org/doi/10.
Structured PICO
Does antecedent hypertension increase the risk of heart failure, adverse ventricular remodeling, and mortality in patients after myocardial infarction?
P
Population
1,093 consecutive patients with acute myocardial infarction
I
Intervention
Antecedent hypertension
C
Comparator
Normotensive (no antecedent hypertension)
O
Outcome
Clinical heart failure, ventricular remodeling, neurohormonal activation, and mortality after myocardial infarctionhard clinical
Antecedent hypertension in patients with acute myocardial infarction is associated with greater neurohormonal activation, adverse ventricular remodeling, and significantly higher rates of heart failure and mortality.
Cite This Study
Richards et al. (2002) studied this question.