December 15, 1998Circulation
Regular Physical Exercise Corrects Endothelial Dysfunction and Improves Exercise Capacity in Patients With Chronic Heart Failure
Why the study?
Does systemic exercise training improve endothelium-mediated arteriolar vasodilation and exercise capacity in patients with chronic heart failure?
Population
20 patients with chronic heart failure, randomized to a training group or a control group.
Comparison
Systemic exercise training for 6 months. vs Control group (no exercise training).
Design
RCT, prospectively randomized
Follow-up
6 months
Authors
Discussion
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Member takes
Implication
Supports exercise training to improve endothelial function and capacity in HF; confirms benefits in this RCT.
Structured PICO
Does systemic exercise training improve endothelium-mediated arteriolar vasodilation and exercise capacity in patients with chronic heart failure?
P
Population
20 patients with chronic heart failure (CHF), randomized to a training group (n=10, LVEF 24+/-4%) or a control group (n=10, LVEF 23+/-3%).
I
Intervention
Systemic exercise training for 6 months.
C
Comparator
Control group (no exercise training).
O
Outcome
Endothelium-mediated arteriolar vasodilation of the lower limb (measured by peripheral blood flow in response to acetylcholine and L-NMMA) and peak oxygen uptake at 6 months.surrogate
Regular physical exercise in patients with chronic heart failure significantly improves endothelial dysfunction and exercise capacity.
Cite This Study
Hambrecht et al. (1998) studied this question.