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May 4, 2026Antioxidants0 citationsOpen Access

Caffeine Supplementation Improves Fertilization and Embryo Development in Advanced Maternal Age

Antioxidant Supplementation with Caffeine During Rescue In Vitro Maturation Improves Fertilization and Embryo Development in Women of Advanced Maternal Age

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Authors

GLGyungbin LeeCHA UniversityJEJin Hee EumMaria Fertility HospitalTKTae Hyung KimMaria Fertility Hospital

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Overview

Randomized trial evaluates caffeine's impact on embryo development in women of advanced maternal age, suggesting enhanced maturation effects.

Key Points

  • This study investigates whether caffeine supplementation during rescue in vitro maturation enhances the developmental competence of immature oocytes in advanced maternal age.
  • Transient caffeine exposure during rescue in vitro maturation of immature oocytes obtained during conventional IVF cycles.
  • Comparison of fertilization rates and embryo development between caffeine-treated and control groups.
  • Assessment of embryonic development outcomes including fertilization rate and good-quality embryo formation.
  • Caffeine supplementation significantly improved fertilization efficiency and the proportion of good-quality embryos compared to controls.
  • Effects of caffeine were most pronounced in women aged ≥ 37 years.
  • Time-lapse analysis showed synchronized developmental kinetics in embryos from caffeine-treated oocytes.

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/69f8375e3ed186a7399818eahttps://doi.org/10.3390/antiox15050555
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Caffeine Supplementation Enhances Aged Human Oocyte Quality and Embryo Development in In Vitro Fertilization: A Retrospective Paired Study2026
  2. 2Rescue In Vitro Maturation of a Germinal Vesicle Oocyte Leading to Pregnancy in a Case of Unexplained Infertility2025
  3. 3Chemical reversion of age-related oocyte dysfunction fails to enhance embryo development in a bovine model of postovulatory aging2024 · 2 citations
  4. 4Treatment of human oocytes with extracellular vesicles from follicular fluid during rescue <i>in vitro</i> maturation enhances maturation rates and modulates oocyte proteome and ultrastructure2026
  5. 5Treatment of human oocytes with extracellular vesicles from follicular fluid during rescue <i>in vitro</i> maturation enhances maturation rates and modulates oocyte proteome and ultrastructure2026