June 26, 2007Circulation
Serial Biomarker Measurements in Ambulatory Patients With Chronic Heart Failure
Why the study?
Do serial measurements of cTnT and BNP improve risk assessment for adverse clinical events in ambulatory patients with chronic heart failure?
Population
190 ambulatory patients with stable chronic heart failure, NYHA class III-IV
Design
Cohort
Follow-up
2 years
Authors
Discussion
Loading...
Member takes
Implication
Combined elevations identify highest-risk chronic HF patients; hypothesis-generating and requires prospective validation before guiding care.
Structured PICO
Do serial measurements of cTnT and BNP improve risk assessment for adverse clinical events in ambulatory patients with chronic heart failure?
P
Population
190 ambulatory patients with stable chronic heart failure, NYHA class III-IV
I
Intervention
Serial measurements of cardiac troponin T (cTnT) and B-type natriuretic peptide (BNP) every 3 months for 2 years
O
Outcome
Composite of death, cardiac transplantation, or hospitalizationcomposite
Serial measurements of cTnT and BNP in stable chronic heart failure patients provide significant prognostic value, with combined elevations indicating the highest risk of adverse events.
Cite This Study
Miller et al. (2007) studied this question.