C-Reactive Protein and the 10-Year Incidence of Coronary Heart Disease in Older Men and Women
Why the study?
Does elevated baseline CRP predict the 10-year incidence of coronary heart disease in older men and women without prior vascular diseases?
Population
3,971 men and women ≥65 years of age without prior vascular diseases
Comparison
Elevated baseline C-reactive protein (CRP >3 mg/L) vs Normal baseline C-reactive protein (CRP <1 mg/L)
Design
Cohort
Follow-up
10 years
Authors
Discussion
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Member takes
Implication
Elevated CRP may refine CHD risk prediction in older adults; extends prior observational data but leaves causal role and interventions open.
Structured PICO
Does elevated baseline CRP predict the 10-year incidence of coronary heart disease in older men and women without prior vascular diseases?
P
Population
3,971 men and women ≥65 years of age without prior vascular diseases
I
Intervention
Elevated baseline C-reactive protein (CRP >3 mg/L)
C
Comparator
Normal baseline C-reactive protein (CRP <1 mg/L)
O
Outcome
10-year incidence of coronary heart disease (defined as myocardial infarction or coronary death)composite
Elevated CRP (>3 mg/L) is associated with an increased 10-year risk of coronary heart disease in older adults without prior vascular disease, providing prognostic information beyond conventional risk assessment.
Cite This Study
Cushman et al. (2005) studied this question.