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May 6, 2026Circulation

Abstract MPTH77: Genome-wide Characterization of Fourteen Circulating Metals and Possible Contribution to Cardiovascular-Kidney-Metabolic Syndrome

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Key result

GWAS meta-analysis identifies 38 loci for circulating metals linked to cardiovascular-kidney-metabolic traits.

  • P<5x10^-8
  • n=15,054

Population

15,054 multi-ethnic participants

Design

Meta-analysis

Authors

GLGuning LiuThe Bronx DefendersNNNgoc Quynh NguyenUniversity of Texas Health Science Center at DallasTATaryn AlkisThe University of Texas Health Science Center at Houston

Discussion

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Implication

Novel genetic loci associated with circulating trace metals suggest a biologically plausible role for metals in cardiovascular-kidney-metabolic syndrome.

Key Points

  • This research explores the relationship between circulating trace metals and genetic variants in the context of cardiovascular-kidney-metabolic syndrome.
  • Conducted genome-wide association analysis of 14 trace metals in the Atherosclerosis Risk in Communities Study
  • Evaluated associations separately for Black and White participants
  • Performed phenome-wide association analyses and Mendelian Randomization with CKM traits
  • Identified 38 genetic loci associated with 14 circulating metal levels
  • Notable associations included variants linked to blood pressure and coronary artery disease
  • Demonstrated modest to moderate effects of metals like iron and barium on CKM traits

Study Design

Type

Meta-Analysis (n=15,054)

Multicenter

Yes

Structured PICO

P
Population
15,054 multi-ethnic participants analyzed to identify genetic variants associated with 14 circulating trace metals and their potential contribution to cardiovascular-kidney-metabolic syndrome.
E
Exposure
Genetic variants associated with 14 circulating trace metals
O
Outcome
Genetic loci associated with circulating metal levels and their association with cardiovascular-kidney-metabolic (CKM) traits

Main Result

p-value: p=<5x10^-8

Novel genetic loci associated with circulating trace metals suggest a biologically plausible role for metals in cardiovascular-kidney-metabolic syndrome.

Cite This Study

Liu et al. (2026) conducted a meta-analysis in Cardiovascular-kidney-metabolic (CKM) syndrome (n=15,054). Circulating trace metals and related genetic variants vs. Reference alleles / lower metal levels was evaluated on Genetic loci associated with 14 circulating metal levels (p=<5x10^-8). Genome-wide association analysis identified 38 genetic loci (18 novel) associated with 14 circulating metal levels (p<5x10^-8), with Mendelian randomization showing effects on CKM traits.

synapsesocial.com/papers/69fa8eac04f884e66b531106https://doi.org/10.1161/cir.153.suppl_1.mpth77
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans2024 · 26 citations
  2. 2Genetically predicted the causal relationship between blood metal levels and ischemic stroke risk based on Asian ethnicity2025
  3. 3Cobalt mediates stage-specific toxicity of metal mixtures in cardiovascular–kidney–metabolic syndrome2025
  4. 4Abstract MP73: The Association of Urinary Metals With Cardiovascular Disease Incidence and All-Cause Mortality in the Multi-Ethnic Study of Atherosclerosis (MESA)2024
  5. 5Urinary metal exposure, systemic inflammation, and advanced cardiovascular-kidney-metabolic syndrome risk in US adults2026