What question did this study set out to answer?

To investigate the effects of novel ciprofloxacin-lipid conjugates on biofilms and antibacterial activity.

May 6, 2026Journal of Medicinal Chemistry0 citations

Disrupting Biofilms and Enhancing Antibacterial Activity via Novel Ciprofloxacin-Lipid Conjugates

RKRahul KumarInstitute of Himalayan Bioresource Technology KPKishan Kumar ParidaNational Institute of Pharmaceutical Education and Research ADAman DalalNational Institute of Pharmaceutical Education and Research

Puntos clave

To investigate the effects of novel ciprofloxacin-lipid conjugates on biofilms and antibacterial activity.
Tested ciprofloxacin-lipid conjugates for cytotoxic effects against HepG2 and J774A cells at 100 μg/mL concentrations.
Evaluated antibacterial activity against biofilms.
Analyzed the targeting effectiveness of modified ciprofloxacin derivatives.
Ciprofloxacin-lipid conjugates showed no cytotoxic effects at the tested concentration.
Demonstrated enhanced antibacterial activity against bacterial biofilms.
Indicated potential for further development of lipophilic-based CIP conjugates.

Resumen

exhibited no cytotoxic effect against both HepG2 and J774A at concentrations of 100 μg/mL. Collectively, these findings open new avenues for the development of lipophilic-based CIP conjugates as modified ciprofloxacin derivatives for targeting bacterial biofilms and DNA gyrase.

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Cite This Study

Kumar et al. (Mon,) studied this question.

synapsesocial.com/papers/69fa983604f884e66b53206c https://doi.org/https://doi.org/10.1021/acs.jmedchem.6c00137

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