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May 6, 2026CellsOpen Access

UGT2B15 Acts as a Critical Detoxification Barrier Against Chemi-Cal-Induced Hepatotoxicity and Carcinogenesis via the Androgen Receptor Axis

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Authors

YZYiru ZhaoYWYue WangLYLi Y

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Overview

Targeted sequencing reveals UGT2B15's role in hepatotoxicity and cancer progression, suggesting a chemopreventive strategy.

Key Points

  • This study investigates the role of UGT2B15 in detoxification and its relationship with hepatotoxicity and carcinogenesis.
  • Targeted sequencing of ten liver-enriched UGT genes in HCC tissues
  • Expression analysis of UGT2B15 mRNA and protein levels
  • Correlation studies with overall survival in TCGA cohorts
  • Transcriptomic profiling post-UGT2B15 knockdown in HCC cells
  • In vitro and in vivo assessment of hepatotoxicity using CCl4 and ethanol.
  • Identified mutation frequencies in UGT2B15 (44.74%) and downregulation of its expression in tumors
  • Higher UGT2B15 levels associated with improved overall survival (HR = 1.724)
  • Androgen receptor regulates UGT2B15 expression with dihydrotestosterone inducing increases
  • UGT2B15 deficiency increased susceptibility to CCl4 and ethanol-induced hepatotoxicity
  • Established the AR-UGT2B15 axis as crucial for protecting against chemical-induced liver injury.

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/69fa989404f884e66b532643https://doi.org/10.3390/cells15090824
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