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April 24, 2026BMC CancerOpen Access

Systematic transcriptomic analysis of UDP-glucuronosyltransferases reveals UGT2B11 as a diagnostic and metabolic marker in hepatocellular carcinoma

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Authors

HJHojin JungAjou UniversityGBGeum Ok BaekAjou UniversityMYMoon Gyeong YoonGerman Cancer Research Center

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Implication

Comprehensive transcriptomic analysis reveals UGT2B11's diagnostic and metabolic potential in hepatocellular carcinoma, indicating important implications for disease monitoring.

Key Points

  • This research aims to explore the transcriptomic landscape of UDP-glucuronosyltransferases in hepatocellular carcinoma and identify UGT2B11 as a potential diagnostic marker.
  • Conducted a multi-cohort transcriptomic analysis across several databases including TCGA-LIHC and GepLiver.
  • Evaluated the expression levels of 19 UGT family genes and their association with HCC.
  • Performed correlational analyses with metabolic and immune pathways.
  • UGT2B11 showed significant upregulation in HCC compared to normal tissues with area-under-the-curve values from 0.79 to 0.84 for diagnostic performance.
  • Higher UGT2B11 expression correlates with immune cell signatures, especially Tregs.
  • Pathway analyses highlight associations with glucuronidation and mTORC1 signaling.

Cite This Study

Jung et al. (2026) studied this question.

synapsesocial.com/papers/69eb0899553a5433e34b37a5https://doi.org/10.1186/s12885-026-16066-3
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