Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 6, 2026Pediatric Blood & Cancer

Outcomes of Myeloid Leukemia Associated With Down Syndrome Treated With a Reduced‐Intensity Protocol: A Multicenter Experience in Argentina

View Full Paper
Ask AI
Bookmark
Share

Authors

ADAlejandra DeanaInstituto Argentino de Diagnóstico y TratamientoSGSergio Miguel GómezInstituto Argentino de Diagnóstico y TratamientoLMLorena MoránInstituto Argentino de Diagnóstico y Tratamiento

Discussion

Loading...

Member takes

Overview

Multicenter study shows 80% survival in pediatric patients with myeloid leukemia and Down syndrome, indicating the need for improved care strategies.

Key Points

  • This study aims to evaluate survival outcomes in pediatric patients with myeloid leukemia associated with Down syndrome.
  • Conducted a multicenter retrospective study of 49 patients with ML-DS (≤18 years) in Argentina
  • All patients treated with the GATLA 8-LMAP-2007 protocol, a reduced-intensity regimen
  • Survival estimates used Kaplan-Meier method, with comparisons via log-rank test.
  • At 48 months, overall survival and event-free survival were both 80.3%
  • Cumulative incidence of relapse was 6.9% and treatment-related mortality was 12.5%
  • Most patients were ≤2 years old and 75.5% had FAB M7 subtype.

Cite This Study

Deana et al. (2026) studied this question.

synapsesocial.com/papers/69faa30204f884e66b53393bhttps://doi.org/10.1002/1545-5017.70375
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CPX-351 in Down syndrome-associated Myeloid Leukemia: Results and Prognostic Factors from the Phase 3 ML-DS 2018 Trial2025 · 7 citations
  2. 2Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: experience on Pediatric Oncology Group AML Study 8498 [see comments]1992 · 258 citations
  3. 3Molecular risk markers define risk of relapse in myeloid leukemia of Down syndrome beyond measurable residual disease2025 · 4 citations
  4. 4Outcomes of down syndrome-related myeloid leukemia in Turkiye: a multicenter retrospective observational cohort study by the Turkish Pediatric Hematology Association2026
  5. 5Guideline for treating relapsed or refractory myeloid leukemia in children with Down syndrome2024 · 6 citations