Evaluation of a Novel Calcium-Binding Peptide for Enamel Remineralization: An In Vitro SEM-EDX Study

Objectives: The increasing demand for biocompatible and effective alternatives to fluoride in enamel remineralization has prompted the development of novel synthetic peptides with a high affinity for calcium. This in vitro study aimed to assess the remineralization potential of one such peptide on artificially induced carious lesions in both primary and permanent enamel, in comparison with fluoride and untreated controls. Materials and Methods: = 144). Scanning electron microscopy with energy dispersive X-ray (SEM-EDX) analysis was performed at initial, after demineralization, and after pH cycling. Statistical Analysis: < 0.05. Conclusion: This study suggests that novel peptide-based agents may offer effective remineralization in early enamel lesions, particularly in primary teeth. They may serve as promising alternatives to fluoride in pediatric dentistry.