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May 7, 2026Endocrine Metabolic & Immune Disorders - Drug Targets

Changes in Biochemical Parameters and TheirCorrelation with Disease Severity in Patients withMetabolic Associated Fatty Liver Disease(MAFLD): A Cross-Sectional Study

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Authors

YZYuexia ZhangYFY A FengCYConglei You

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Overview

Cross-sectional study investigates biochemical changes linked to MAFLD severity, suggesting improved screening methods.

Key Points

  • The study aims to analyze biochemical changes in patients with Metabolic-Associated Fatty Liver Disease (MAFLD) and their relation to disease severity.
  • Cross-sectional design enrolling MAFLD patients and healthy controls at Beijing Jishuitan Hospital (Aug 2021–Oct 2024).
  • 1:1 Propensity score matching to adjust for age, gender, and body mass index (BMI).
  • Multivariate logistic regression and ROC analysis were used to identify risk factors and evaluate diagnostic performance.
  • MAFLD patients had significantly higher levels of TG, TC, apoA, FPG, FINS, ALT, AST, ALP, and γGT than healthy controls (all p < 0.05).
  • Biochemical abnormalities worsened progressively with liver severity, with significant changes in ALT, AST, and γ-GT (p < 0.05).
  • The Combined Model (ALT + γ-GT + BMI) showed the highest diagnostic efficacy (AUC = 0.824), outperforming individual biomarkers.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69fc2ca48b49bacb8b348102https://doi.org/10.2174/0118715303416030260417105509
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The association of multiple metabolic disorders with the severity of fasting blood glucose and hepatic steatosis in a Chinese population with MAFLD: a cross-sectional study of over 3000 participants2025 · 2 citations
  2. 2The development and evaluation of nine non-conventional lipid parameters for metabolic dysfunction-associated fatty liver disease in Chinese medical health examination adults: a single-center retrospective study2026 · 2 citations
  3. 3Clinical and Comorbidity Profile of Metabolic Dysfunction-Associated Fatty Liver Disease: A Retrospective Cohort Study2025
  4. 4Comparative Analysis of Metabolic and Inflammatory Biomarker Profiles in Phenotypes of Metabolic Dysfunction-Associated Fatty Liver Disease2025 · 2 citations
  5. 5A Comparative Study of MAFLD as a Predictor for Metabolic Disease Therapies Against NAFLD in Repeated Health Check-Ups: A Novel Perspective on Fatty Liver2024