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September 16, 2025Journal of College of Physicians And Surgeons PakistanOpen Access

Comparative Analysis of Metabolic and Inflammatory Biomarker Profiles in Phenotypes of Metabolic Dysfunction-Associated Fatty Liver Disease

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Authors

SNSumbal NidaArmed Forces Institute of PathologyDKDilshad Ahmed KhanArmed Forces Institute of PathologyMKMuhammad Qaiser Alam KhanArmed Forces Institute of Pathology

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Implication

Comparative observational study reveals metabolic dysfunction-associated fatty liver disease biomarkers in distinct phenotypes, indicating the severity of conditions.

Key Points

  • Distinct biomarker profiles exist among metabolic dysfunction-associated fatty liver disease phenotypes, with T2D-MAFLD showing the most severe conditions.
  • Elevated lipid profiles, liver enzymes, and inflammatory cytokines are present in T2D-MAFLD patients compared to other groups.
  • Obese-MAFLD patients display significant triglyceride and cytokine elevation, while lean-MAFLD shows mild disturbances.
  • Identifying phenotype-specific biomarkers may enhance early detection and treatment strategies for metabolic dysfunction-associated fatty liver disease.

Cite This Study

Nida et al. (2025) studied this question.

synapsesocial.com/papers/68d44f8c31b076d99fa57517https://doi.org/10.29271/jcpsp.2025.09.1106
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Also Consider

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  1. 1Changes in Biochemical Parameters and Their Correlation with Disease Severity in Patients with Metabolic Associated Fatty Liver Disease (MAFLD): A Cross-Sectional Study2026
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  3. 3Clinical and Comorbidity Profile of Metabolic Dysfunction-Associated Fatty Liver Disease: A Retrospective Cohort Study2025
  4. 4The MAFLD definition identifies three homogenous groups of patients2024 · 8 citations
  5. 5Comparative study of MAFLD as a predictor of metabolic disease treatment for NAFLD2024 · 7 citations