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October 20, 2022Frontiers in MedicineOpen Access

Compared with the reference group, patients with MAFLD-T2D and MAFLD-MUHO had the highest risk for CVD regarding EAT (OR 15.87, 95% CI 4.26-59.12 and OR 17.60, 95% CI 6.71-46.20, respectively), and MAFLD-T2D had increased risk regarding CAC (OR 6.56, 95% CI 2.18-19.76).

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Why the study?

To better understand patient heterogeneity in fatty liver disease, MAFLD was proposed as a new nomenclature for NAFLD, motivating evaluation of cardiovascular risk across FLD subtypes.

Do different subtypes of metabolic dysfunction-associated fatty liver disease (MAFLD) increase cardiovascular risk assessed by epicardial adipose tissue and coronary artery calcium compared to patients without fatty liver disease or metabolic dysfunction?

Population

370 patients with or without FLD

Comparison

FLD subtypes and non-FLD with MD vs patients without FLD nor MD

Design

Cross-sectional study

Authors

CPCarolina M. PerdomoJNJorge M. Núñez‐CórdobaAEAna Ezponda

Discussion

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Overview

MAFLD-T2D/MUHO may flag higher CVD risk via EAT/CAC; hypothesis-generating and should not yet change practice.

Structured PICO

Do different subtypes of metabolic dysfunction-associated fatty liver disease (MAFLD) increase cardiovascular risk assessed by epicardial adipose tissue and coronary artery calcium compared to patients without fatty liver disease or metabolic dysfunction?

P
Population
370 patients with and without fatty liver disease (FLD) and its subtypes, including metabolic dysfunction-associated fatty liver disease (MAFLD).
I
Intervention
Presence of metabolic dysfunction-associated fatty liver disease (MAFLD) subtypes (MAFLD-T2D, MAFLD-OW [MHO and MUHO], MAFLD-MD, and non-MD FLD).
C
Comparator
Patients without FLD and without metabolic dysfunction (non-FLD nor MD).
O
Outcome
Cardiovascular risk assessed through epicardial adipose tissue (EAT) and coronary artery calcium (CAC) measured by computed tomography.surrogate

MAFLD phenotypes, particularly those with type 2 diabetes or metabolically unhealthy obesity, are associated with significantly increased cardiovascular risk as measured by epicardial adipose tissue and coronary artery calcium.

Cite This Study

Perdomo et al. (2022) studied this question.

synapsesocial.com/papers/6a82b2023096299d011c2c39https://doi.org/10.3389/fmed.2022.1023583
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Also Consider

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