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November 13, 1979Biochemistry

Concerted regulation of cardiac sarcoplasmic reticulum calcium transport by cyclic adenosine monophosphate dependent and calcium-calmodulin-dependent phosphorylations

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Authors

CPChristian J. Le PeuchCentre National de la Recherche ScientifiqueJHJacques HaiechCité des Sciences et de l'IndustrieJDJacques DemailleUniversity of Geneva

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Implication

Dual cAMP- and CaM-dependent phosphorylations may concertedly regulate cardiac SR Ca2+ transport; leaves open their in vivo roles in excitation-contraction coupling.

Key Points

  • Investigate how cyclic adenosine monophosphate (cAMP)-dependent and calcium-calmodulin-dependent protein kinase phosphorylations concertedly modulate calcium transport in cardiac sarcoplasmic reticulum.
  • Assayed calcium uptake kinetics in isolated cardiac sarcoplasmic reticulum membrane preparations.
  • Evaluated the distinct and combined effects of cAMP-dependent protein kinase and calcium-calmodulin-dependent protein kinase phosphorylations on transport activity.
  • Both cAMP-dependent and calcium-calmodulin-dependent phosphorylation pathways individually stimulate calcium transport in cardiac sarcoplasmic reticulum vesicles.
  • Concerted phosphorylation via both signaling pathways produces additive or synergistic activation of calcium uptake rates.

Cite This Study

Peuch et al. (1979) studied this question.

synapsesocial.com/papers/69fcb7c44f95092fbe78f869https://doi.org/10.1021/bi00590a019
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Also Consider

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  1. 1Adenosine 3':5'-monophosphate dependent protein kinase from bovine heart. Characterization of the catalytic subunit1977 · 216 citations
  2. 2Effects of adenosine 3':5'-monophosphate-dependent protein kinase on sarcoplasmic reticulum isolated from cardiac and slow and fast contracting skeletal muscles.1976 · 191 citations
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