Why the study?
With a growing number of CIED patients undergoing radiotherapy for cancer, the prevalence and predictors of radiotherapy-induced CIED malfunctions were not defined.
What is the prevalence and what are the predictors of radiotherapy-induced device malfunction in patients with cardiac implantable electronic devices?
Population
3121 patients with CIEDs undergoing radiotherapy across 32 studies
Design
Systematic review and meta-analysis
Authors
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Warrants neutron-energy caution and device-specific monitoring during radiotherapy in CIED patients; meta-analysis confirms elevated malfunction risks by device type.
What is the prevalence and what are the predictors of radiotherapy-induced device malfunction in patients with cardiac implantable electronic devices?
Radiotherapy-induced CIED malfunction occurs in approximately 6.6% of patients, with significantly higher risk associated with neutron-producing energies and complex devices (ICD/CRT-D), while radiation dose at the CIED does not significantly impact risk unless >10 Gy.
Malavasi et al. (2022) studied this question.
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