Why the study?
Does continuous infusion of GLP-1 improve survival in spontaneously hypertensive, heart failure-prone rats?
Population
50 spontaneously hypertensive, heart failure-prone (SHHF) rats at 9 months of age
Comparison
Continuous infusion of GLP-1 for 3 months vs Continuous infusion of saline for 3 months
Design
Preclinical, randomized
Follow-up
3 months
Authors
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GLP-1 survival benefit in SHHF rats does not alter HF care; leaves open translation to human disease.
Does continuous infusion of GLP-1 improve survival in spontaneously hypertensive, heart failure-prone rats?
Chronic GLP-1 infusion significantly improves survival and preserves left ventricular function in a rat model of spontaneous hypertension and heart failure.
Poornima et al. (2008) studied this question.
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