Coreactant-Free and Label-Free Eletrochemiluminescence Immunosensor for Copeptin Based on Luminescent Immuno-Gold Nanoassemblies

mol/L. The detection limit of the ECL immunosensor is at least 2 orders of magnitude lower than that of sandwich immunoassays based on labeling technology. Also, the ECL immunosensor does not need any coreactant and avoids complicated labeling and purification procedure. It is ultrasensitive, simple, specific, and low-cost. This work reveals that the proposed luminescent immuno-gold nanoassemblies are ideal nanointerfaces for the construction of immunosensors. The proposed strategy may be used for the determination of other antigens if corresponding antibodies are available.