Class IC antiarrhythmic agents can induce ST segment elevation in right precordial leads, mimicking or unmasking Brugada syndrome and highlighting a mechanism for drug-induced proarrhythmia.
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Warrants ECG vigilance during Class IC initiation; leaves open prospective validation of Brugada-related proarrhythmia risk.
Krishnan et al. (1998) studied this question.
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