Why the study?
Does ultrasonic energy delivered via a wire probe induce arterial relaxation and ablate plaque in preclinical vascular models?
Population
Rabbit thoracic aortas, totally occluded atherosclerotic human cadaver iliofemoral arteries, and a…
Comparison
Ultrasonic energy delivered via a ball-tipped… vs Distal (untreated) control segments.
Design
Preclinical
Authors
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Ultrasonic energy merits further preclinical testing as a nonthermal modality; leaves open translation to safe human arterial recanalization.
Does ultrasonic energy delivered via a wire probe induce arterial relaxation and ablate plaque in preclinical vascular models?
Ultrasonic energy delivered via a flexible-wire probe produces dose-dependent, endothelium-independent smooth muscle relaxation and effectively ablates atherosclerotic plaque without significant thermal injury.
Fischell et al. (1991) studied this question.