What question did this study set out to answer?

This meta-analysis aims to update the understanding of how different antihypertensive drugs affect left ventricular hypertrophy in essential hypertension.

March 1, 1998Nephrology Dialysis TransplantationOpen Access

Meta-analysis. Update on reversal of left ventricular hypertrophy in essential hypertension (a meta-analysis of all randomized double-blind studies until December 1996)

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Why the study?

Do different classes of antihypertensive drugs reduce left ventricular hypertrophy in patients with essential hypertension?

Key Points

This meta-analysis aims to update the understanding of how different antihypertensive drugs affect left ventricular hypertrophy in essential hypertension.
Meta-analysis of double-blind, randomized, controlled trials published until December 1996.
Analysis included studies evaluating the reduction of left ventricular mass with various antihypertensive therapies.
Data extraction was conducted by two independent investigators.
Left ventricular mass index reduced by 12% with ACE-inhibitors (95% CI: 9.0-14.5%).
Calcium channel blockers decreased left ventricular mass index by 11% (95% CI: 7.8-13.7%).
ACE-inhibitors and calcium channel blockers were significantly more effective than beta-blockers (P<0.05).

Structured PICO

Do different classes of antihypertensive drugs reduce left ventricular hypertrophy in patients with essential hypertension?

Population

1,715 patients with essential hypertension from 50 randomized double-blind studies (13 placebo arms, n=165; 89 active treatment arms, n=1550)

Intervention

Antihypertensive therapy (ACE-inhibitors, calcium channel blockers, beta-blockers, or diuretics)

Comparator

Placebo or other antihypertensive drug classes

Outcome

Reduction of left ventricular masssurrogate

Discussion

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Implication

ACE-inhibitors and calcium channel blockers regress left ventricular mass more than beta-blockers; confirms class-specific effects in hypertension.

Cite This Study

Schmieder et al. (1998) studied this question.

synapsesocial.com/papers/69fd29ba30a474415f89e1f9 https://doi.org/10.1093/ndt/13.3.564

Topics

Hypertension management

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Implication

ACE-inhibitors and calcium channel blockers regress left ventricular mass more than beta-blockers; confirms class-specific effects in hypertension.

Meta-analysis. Update on reversal of left ventricular hypertrophy in essential hypertension (a meta-analysis of all randomized double-blind studies until December 1996)

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Meta-analysis. Update on reversal of left ventricular hypertrophy in essential hypertension (a meta-analysis of all randomized double-blind studies until December 1996)

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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