Key result
Antihypertensive therapy with hydrochlorothiazide alone or with methyldopa reduced end-diastolic relative wall thickness from 0.50 to 0.45 (P<0.01) over a mean of 11 months.
Why the study?
Does antihypertensive therapy with hydrochlorothiazide alone or with methyldopa reduce left ventricular hypertrophy in previously untreated subjects with essential hypertension?
Cohort (n=27)
Does antihypertensive therapy with hydrochlorothiazide alone or with methyldopa reduce left ventricular hypertrophy in previously untreated subjects with essential hypertension?
p-value: p=<0.01
Effective blood pressure control with hydrochlorothiazide and/or methyldopa can lead to significant reversal of left ventricular hypertrophy in patients with asymptomatic essential hypertension.
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May support LVH regression with thiazide-based therapy in essential hypertension; leaves open confirmation in randomized trials.
Reichek et al. (1982) conducted a cohort in Essential hypertension with left ventricular hypertrophy (n=27). Antihypertensive therapy (hydrochlorothiazide alone or with methyldopa) vs. Baseline (pre-treatment) was evaluated on End-diastolic relative wall thickness (p=<0.01). Antihypertensive therapy with hydrochlorothiazide alone or with methyldopa reduced end-diastolic relative wall thickness from 0.50 to 0.45 (P<0.01) over a mean of 11 months.
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