Why the study?
Does aggressive treatment with diuretics and other antihypertensive agents improve left ventricular function and mass in untreated hypertensive patients?
Population
12 untreated hypertensive patients
Design
Cohort
Follow-up
6 months
Authors
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Supports LVH regression with aggressive BP lowering in severe hypertension; hypothesis-generating and requires RCTs before practice change.
Does aggressive treatment with diuretics and other antihypertensive agents improve left ventricular function and mass in untreated hypertensive patients?
Aggressive blood pressure reduction in severe hypertension leads to early, temporary improvements in systolic function and longer-term regression of left ventricular hypertrophy.
Khatri et al. (1980) studied this question.
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