What question did this study set out to answer?

To assess changes in left ventricular structure and mass using echocardiography before and after 9 months of blood pressure control in patients with essential hypertension.

December 1, 1980Clinical Science

Effect of Blood Pressure Control on Left Ventricular Hypertrophy in Patients with Essential Hypertension

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Why the study?

Does blood pressure control improve left ventricular structure and function in patients with essential hypertension?

Population

22 patients with essential hypertension

Comparison

Blood pressure control for 9 months vs Baseline (before blood pressure control)

Design

Cohort

Follow-up

9 months

Authors

FDFG DunnUniversity of Glasgow BBB. BastianCardiac Society of Australia and New Zealand TLT. D. V. LawrieCaterpillar (United States)

Discussion

Member takes

Implication

BP control was associated with LVH regression; extends small-cohort observations but leaves outcome impact open.

Key Points

To assess changes in left ventricular structure and mass using echocardiography before and after 9 months of blood pressure control in patients with essential hypertension.
Evaluated 22 patients with essential hypertension (N=22) using echocardiography before and after 9 months of blood pressure control.
Categorized patients into those with normal baseline echocardiograms (group 1, n=9) and those with baseline left ventricular hypertrophy (group 2, n=13).
Patients with baseline hypertrophy (group 2) demonstrated significant reductions in posterior wall thickness (P < 0.01), septal wall thickness (P < 0.025), and left ventricular mass (P < 0.005).
A reduction in posterior wall thickness of ≥ 3 mm occurred in 6 of 13 patients with hypertrophy, with the extent of regression showing no clear relationship to initial blood pressure, magnitude of blood pressure reduction, or follow-up duration.

Structured PICO

Does blood pressure control improve left ventricular structure and function in patients with essential hypertension?

Population

22 patients with essential hypertension (9 with normal baseline echocardiograms, 13 with echocardiographic evidence of left ventricular hypertrophy)

Intervention

Blood pressure control (multiple therapy) for 9 months

Comparator

Baseline (before blood pressure control)

Outcome

Changes in left ventricular structure and function (posterior wall thickness, septal wall thickness, left ventricular mass) assessed by echocardiography at 9 monthssurrogate

Blood pressure control over 9 months can lead to significant regression of left ventricular hypertrophy in patients with essential hypertension.

Limitations

Not possible to say whether any specific therapy was beneficial to regression since most of the patients were on multiple therapy

Cite This Study

Dunn et al. (1980) studied this question.

synapsesocial.com/papers/6a7055c835aa2c282ce1a476 https://doi.org/10.1042/cs059441s

Topics

Hypertension management Echocardiography

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Effect of Blood Pressure Control on Left Ventricular Hypertrophy in Patients with Essential Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Topics

Effect of Blood Pressure Control on Left Ventricular Hypertrophy in Patients with Essential Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider