Key result
Treatment withdrawal after regression of left ventricular hypertrophy led to redevelopment of hypertension driven by an increase in cardiac index (from 2.5 to 3.1 L/min/m2; P<0.001).
Why the study?
Does withdrawal of antihypertensive treatment after regression of left ventricular hypertrophy affect systolic function and hemodynamics in hypertensive patients?
Population
23 hypertensive patients
Comparison
Withdrawal of antihypertensive treatment for… vs Baseline (before therapy)
Design
Cohort
Follow-up
20-30 days after treatment withdrawal
Authors
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May warrant caution withdrawing therapy post-LVH regression; leaves open hemodynamic drivers of recurrence.
Observational (n=23)
Does withdrawal of antihypertensive treatment after regression of left ventricular hypertrophy affect systolic function and hemodynamics in hypertensive patients?
Absolute Event Rate: 3.1% vs 2.5%
p-value: p=<0.001
After regression of left ventricular hypertrophy and subsequent treatment withdrawal, systolic function is maintained and the redevelopment of hypertension is primarily driven by higher cardiac output rather than increased peripheral resistance.
Muiesan et al. (1991) conducted an observational in Hypertension with left ventricular hypertrophy (n=23). Treatment withdrawal vs. Before treatment was evaluated on Cardiac index at rest (L/min/m2) (p=<0.001). Treatment withdrawal after regression of left ventricular hypertrophy led to redevelopment of hypertension driven by an increase in cardiac index (from 2.5 to 3.1 L/min/m2; P<0.001).
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