Comparison of T1 mapping techniques for ECV quantification. Histological validation and reproducibility of ShMOLLI versus multibreath-hold T1 quantification equilibrium contrast CMR

100 individuals with a spectrum of disease with variable ECV expansion (50 healthy volunteers, 12 patients with hypertrophic cardiomyopathy, 18 with severe aortic stenosis, 20 with amyloid). A subset of 18 severe AS patients had biopsies for histological correlation, and 17 individuals (10 healthy, 7 amyloid) underwent test-retest reproducibility.

Single breath-hold T1 mapping using Shortened Modified Look-Locker Inversion recovery (ShMOLLI) in equilibrium contrast CMR

Multibreath-hold T1 quantification with heart rate correction (FLASH) in equilibrium contrast CMR

Myocardial extracellular volume (ECV) quantification and correlation between the two techniquessurrogate