Why the study?
Do beta-blockers increase the risk of adverse effects in patients with chronic heart failure with left ventricular systolic dysfunction?
Do beta-blockers increase the risk of adverse effects in patients with chronic heart failure with left ventricular systolic dysfunction?
Beta-blocker therapy in heart failure is associated with small absolute increases in hypotension, dizziness, and bradycardia, but overall reduces medication withdrawal, mortality, and hospitalizations.
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Despite small absolute increases, beta-blockers remain first-line in HFrEF; reinforces net benefit on mortality and hospitalizations.
Ko et al. (2004) studied this question.