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May 8, 2026PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

The Role of Histone Lactylation in Diseases and Intervention by Traditional Chinese Medicine

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Authors

XZXin ZhangQingdao UniversityJDJie DUZLZhao-Huan LI

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Overview

Review discusses the impact of histone lactylation in diseases, showing how Traditional Chinese Medicine can regulate it.

Key Points

  • This review examines the mechanisms of histone lactylation and its associations with various diseases and therapies.
  • Systematic analysis of the role of histone lactylation in regulating transcription and disease progression.
  • Examination of the crosstalk between histone and non-histone lactylation.
  • Review of Traditional Chinese Medicine's effect on lactate metabolism and histone lactylation regulation.
  • Histone lactylation influences cell proliferation, inflammation, and fibrosis, affecting disease outcomes.
  • Traditional Chinese Medicine shows potential in modulating lactylation-related enzymes to treat drug-resistant diseases.
  • A proposed framework links histone lactylation to metabolic processes, highlighting novel therapeutic targets.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69fd7d4abfa21ec5bbf05db4https://doi.org/10.3724/j.pibb.2026.0022
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications2025 · 6 citations
  2. 2Histone lactylation: a novel epigenetic bridge linking cellular metabolism to benign and malignant gynecological diseases2026
  3. 3Lactylation in tissue fibrosis: epigenetic mechanisms, metabolic crosstalk, and therapeutic opportunities2026 · 2 citations
  4. 4Lactate metabolism and protein lactylation in cancer2026 · 7 citations
  5. 5From metabolic reprogramming to epigenetic modification: association network and targeted treatment strategy between histone lactylation and tumor progression2025 · 8 citations