What question did this study set out to answer?

This research aims to assess the effect of remote ischemic conditioning on infarct volume in acute ischemic stroke patients undergoing endovascular treatment.

May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026a2328 Neuroprotective Effect of Remote Ischemic Conditioning in Ischemic Stroke Treated With Mechanical Thrombectomy—protect-I Trial

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This research aims to assess the effect of remote ischemic conditioning on infarct volume in acute ischemic stroke patients undergoing endovascular treatment.
Randomized, open-label trial with blinded endpoint assessment
Patients with anterior circulation large vessel occlusion were randomized to RIC plus standard care or standard care alone
RIC involved four 5-minute cycles of upper-limb ischemia at 200 mmHg followed by reperfusion
Median final infarct volume was 0.311 in the RIC group and 0.278 in the control group
No significant reduction in infarct volume associated with RIC (OR 1.30, 95% CI 0.61–2.79; P = 0.50)
Results remained nonsignificant after adjusting for final TICI score

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Implication

Randomized trial finds remote ischemic conditioning does not reduce infarct volume in acute ischemic stroke patients receiving endovascular treatment, suggesting limited clinical benefit.

Cite This Study

Mechtouff et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e00bfa21ec5bbf062ab https://doi.org/10.1093/esj/aakag023.152

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Implication

Randomized trial finds remote ischemic conditioning does not reduce infarct volume in acute ischemic stroke patients receiving endovascular treatment, suggesting limited clinical benefit.

Abstract Number: Esoc2026a2328 Neuroprotective Effect of Remote Ischemic Conditioning in Ischemic Stroke Treated With Mechanical Thrombectomy—protect-I Trial

Key Points

Discussion

Implication

Cite This Study

Abstract Number: Esoc2026a2328 Neuroprotective Effect of Remote Ischemic Conditioning in Ischemic Stroke Treated With Mechanical Thrombectomy—protect-I Trial

Key Points

Discussion

Implication

Cite This Study

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