Key result
SERIC-EVT trial evaluates if remote ischemic conditioning improves 90-day functional independence after acute stroke thrombectomy.
Why the study?
Many patients undergoing successful recanalization after EVT do not achieve good outcomes, and remote ischemic conditioning may offer neuroprotection.
Does remote ischemic conditioning improve functional independence at 90 days in patients with acute ischemic stroke undergoing endovascular thrombectomy?
RCT (n=498)
Blinded endpoint
1:1
Yes
Does remote ischemic conditioning improve functional independence at 90 days in patients with acute ischemic stroke undergoing endovascular thrombectomy?
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This study protocol outlines a randomized controlled trial to determine if remote ischemic conditioning improves 90-day functional outcomes in patients with acute ischemic stroke undergoing endovascular thrombectomy.
Guo et al. (2022) conducted an RCT in Acute ischemic stroke due to large vessel occlusion of anterior circulation (n=498). Remote ischemic conditioning vs. Sham-RIC (inflation pressure of 60 mmHg twice daily) was evaluated on Proportion of patients with modified Rankin Scale (mRS) score of 0-2 on day 90. The SERIC-EVT trial will randomize 498 patients to determine if remote ischemic conditioning improves 90-day functional independence after thrombectomy for acute ischemic stroke.
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