Why the study?
The role of ticagrelor with or without aspirin after coronary artery bypass graft surgery remains unclear.
Does ticagrelor DAPT or ticagrelor monotherapy reduce saphenous vein graft failure compared to aspirin in patients undergoing coronary artery bypass graft surgery?
Population
1316 patients with 1668 saphenous vein grafts undergoing coronary artery bypass graft surgery
Comparison
Ticagrelor DAPT or ticagrelor monotherapy vs aspirin
Design
Individual patient data meta-analysis of 4 RCTs
Authors
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Ticagrelor DAPT may warrant consideration post-CABG to curb graft failure; extends low-certainty meta-analysis data while bleeding risk persists.
Does ticagrelor DAPT or ticagrelor monotherapy reduce saphenous vein graft failure compared to aspirin in patients undergoing coronary artery bypass graft surgery?
Adding ticagrelor to aspirin after coronary artery bypass graft surgery significantly reduces the risk of vein graft failure but increases the risk of clinically important bleeding, whereas ticagrelor monotherapy shows no significant difference compared to aspirin.
Sandner et al. (2022) studied this question.