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May 8, 2026European Stroke Journal

Abstract Number: Esoc2026a1878 Cost-Effectiveness of Interventions That Improve the First Pass Reperfusion Rate in Acute Ischemic Stroke: A Markov Decision Analysis

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Authors

GSGerard van SpaendonckCMCharles MajoieFCFabiano Cavalcante

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Overview

Randomized trial evaluates cost-effectiveness of improving first pass reperfusion in acute ischemic stroke, suggesting substantial long-term benefits.

Key Points

  • This analysis aims to determine the cost-effectiveness of strategies that improve first pass reperfusion (FPR) rates in acute ischemic stroke (AIS).
  • Developed a Markov decision analysis framework with 2.3 million virtual patients over 20 years.
  • Input clinical data from the MRCLEAN registry, focusing on procedural success and disability outcomes.
  • Calculated cost-effectiveness using variations in FPR improvements and associated costs.
  • Achieving FPR can increase quality of life years (QALY) by 0.89 year.
  • An intervention that increases FPR by α% is cost-effective if it costs less than €712*α per patient.
  • For a 10% improvement in FPR, cost-effectiveness is achieved if priced below €7,120 per use.

Cite This Study

Spaendonck et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e42bfa21ec5bbf0671bhttps://doi.org/10.1093/esj/aakag023.884
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