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May 8, 2026Biotechnology and Applied Biochemistry

Phytocomponents Derived From Naturally Growing Chamaedorea seifrizii as Novel α‐Amylase Inhibitors for Diabetes Management: In Vitro and In Silico Approach

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Authors

ACAmrita ChauhanASArun Dev SharmaIKInderjeet Kaur

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Overview

Randomized trial examines α-amylase inhibition in diabetes management using Chamaedorea seifrizii extracts, suggesting a new drug approach.

Key Points

  • This research aims to identify α-amylase inhibitors derived from Chamaedorea seifrizii for diabetes management.
  • In silico ADMET analysis to assess the safety and absorption of ligand molecules.
  • Kinetic study determining the noncompetitive inhibition of α-amylase by CIAE and CFAE extracts.
  • CIAE and CFAE extracts significantly inhibit α-amylase in a noncompetitive manner.
  • Ligand molecules exhibited good absorption with no harmful effects in the ADMET analysis.

Cite This Study

Chauhan et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e42bfa21ec5bbf06755https://doi.org/10.1002/bab.70178
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In-vitro and in-silico investigation of α-amylase and α-glucosidase inhibition using Chamaecostus cuspidatus leaf for diabetes mellitus2024
  2. 2In silico Evaluation of Plant-Derived Compounds as Potential α-Amylase Inhibitors for Treatment of Type 2 Diabetes2025 · 1 citations
  3. 3Augmentation of α-amylase and α-glucosidase inhibitory properties of Callerya speciosa root extracts: An exploration through simulated human gastrointestinal digestion2024 · 1 citations
  4. 4Design, synthesis, biological evaluation, and in silico characterization of chalcone derivatives as antidiabetic hits2026
  5. 5Computational Insights into the Antidiabetic Potential of Young Fronds of Diplazium esculentum (Retz.) Sw.: In silico Analysis of α-Amylase and α-Glucosidase Inhibition2026