What question did this study set out to answer?

Assess the real-world effectiveness and safety of tenecteplase compared to alteplase in modern stroke care settings.

Abstract Number: Esoc2026a1497 Tenecteplase Versus Alteplase in Evt-Enriched Stroke Care: Real-World Evidence From Over 210,000 Patients

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Observational cohorts evaluate tenecteplase and alteplase outcomes in large stroke populations, suggesting comparable safety and effectiveness.

Assess the real-world effectiveness and safety of tenecteplase compared to alteplase in modern stroke care settings.
Conducted a synthesis of observational studies and registries of tenecteplase and alteplase
Included large-vessel occlusion populations with access to endovascular thrombectomy
Analyzed outcomes such as functional status, symptomatic intracranial hemorrhage, and mortality.
Evidence from 29 studies with over 210,000 patients showed functional outcomes similar between tenecteplase and alteplase
No significant safety issues with tenecteplase; rates of symptomatic intracranial hemorrhage were comparable
Some cohorts noted lower mortality rates with tenecteplase in thrombectomy-focused settings.

Martínez et al. (2026) studied this question.

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Observational cohorts evaluate tenecteplase and alteplase outcomes in large stroke populations, suggesting comparable safety and effectiveness.